Transcriptional effects of gene dose reduction
نویسندگان
چکیده
منابع مشابه
Thyroid dose and dose reduction method from CT scan of head and neck
Introduction: Computed tomography (CT) consists of 11% of all imaging methods, but accounts for approximately 67% of radiation exposure due to diagnostic cases. More than one-third of all CT scans are done in the head and neck area. The thyroid gland is irradiated during CT head and neck. According to studies, this gland has the highest levels of radiation-induced cancer, and i...
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Stochasticity in gene expression affects many cellular processes and is a source of phenotypic diversity between genetically identical individuals. Events in elongation, particularly RNA polymerase pausing, are a source of this noise. Since the rate and duration of pausing are sequence-dependent, this regulatory mechanism of transcriptional dynamics is evolvable. The dependency of pause propens...
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The principal objective of radiation protection is to ensure that the dose received by any individual does not exceed the applicable M.P.D. values.We will discuss in this paper the presents recommendations and technical information related to the design and installation of structural shielding with taking into account the concept of Maximum Permissible Dose equivalent (MPDl as expressed and ...
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Variants of unknown significance in the CAPN3 gene constitute a significant challenge for genetic counselling. Despite the frequency of intronic nucleotide changes in this gene (15-25% of all mutations), so far their pathogenicity has only been inferred by in-silico analysis, and occasionally, proven by RNA analysis. In this study, 5 different intronic variants (one novel) that bioinformatic to...
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ژورنال
عنوان ژورنال: Biology of Sex Differences
سال: 2014
ISSN: 2042-6410
DOI: 10.1186/2042-6410-5-5